She visited a clinic and was referred to our hospital due to suspected transient amaurosis. This symptom lasted 30 min and gradually subsided within 10 min. Nevertheless, she again developed visual disturbance like white-out on her left visual field. She visited an ophthalmologist, but ophthalmologic examination revealed no specific findings. On Day 2, the same visual symptom recurred and subsided within a few minutes. This symptom lasted for only a few minutes. On Day 1, she developed visual disturbance a star-like misty area emerged on her left visual field. Thirteen days after the vaccination (Day 0), she developed left ophthalmalgia and slight headache in the left side of the head. These symptoms subsided within a few days of onset. Seven days after the vaccination, she experienced a sore throat, and bilateral parotid gland pain after further 10 days. Therefore, we propose that SARS-CoV-2 mRNA vaccination may induce transient optic neuritis and perineuritis, associated with anti-MOG antibody in the present case.Ĭonclusion: This is the first case of left optic neuritis and perineuritis associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BNT162b2 mRNA vaccination.Ī 39-year-old woman with a history of single caesarian resection got her first dose of severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) BNT162b2 mRNA vaccine. To our knowledge, only one neuromyelitis optica case was associated with anti-MOG antibody. Her visual disturbance never recurred and her ophthalmalgia and headache subsided only with anti-inflammatory agents.ĭiscussion: Many cases of optic neuritis associated with vaccinations have been reported except for SARS-CoV-2 BNT162b2 mRNA. She was diagnosed with left optic perineuritis after SARS-CoV-2 mRNA vaccination. Test for serum anti-aquaporin 4 antibody was negative, whereas anti-myelin oligodendrocyte glycoprotein (MOG) antibody was positive. MRI on Day 2 suggested slight left optic neural swelling Gadolinium-enhanced MRI on Day 4 revealed left optic perineuritis. On admission (Day 2), she presented with left ophthalmalgia and headache without any other neurological deficits including the movement of eyeballs, visual field, visual acuity, or nystagmus. Backgrounds: To report the first case of left optic neuritis and perineuritis associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BNT162b2 mRNA vaccination.Ĭase presentation: A 39-year-old woman was referred and admitted to our hospital due to transient left visual field abnormality with left ophthalmalgia and headache 12 days after the first vaccination dose of SARS-CoV-2 (BNT162b2).

Mog optic neuritis